Cannabidiol (CBD) Lost in the Fog Created by the Legalize Marijuana Crowd

CBD Molecule
CBD Molecule
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CBD Molecule
CBD Molecule

Cannabidiol (CBD) Lost in the Fog Created by the Legalize Marijuana Crowd

 

First and foremost I as the author of this article am both a libertarian and a business owner.  What that means is I am a true constitutional American.  I believe in your freedom but not at the expense of my own.  Since the 1970 Controlled Substance Act industrial hemp has been lumped into the same controlled substance category as its close cousin marijuana and classified as an illegal drug. The key distinguishing characteristic between hemp and marijuana, both from the genus and species cannabis sativa L., is the percentage of

, the psychoactive ingredient. The generally accepted requirement for industrial hemp is 1% THC or less while marijuana contains at least 3% and sometimes 15% or higher.  As of 2004 Hemp Oil is legal in the same fashion as any other herb would be as long as it contains less than 0.3% THC.  It is legal for USE and Sale it is not legal to grow hemp in the United States.

 

The legalize marijuana crowd has intermixed the words and flat out lied about marijuana’s effects coupled with the fact that plants look similar in a photograph makes it easy for someone to ignore realities and chase who has the most money.  In this world selling a High is profitable and that makes them the winner.  You can’t get high from CBD and that spawns the willful confusion.  Images are powerful and it was film called Refer Madness that planted the image in the minds of politicians ignorant of industry to start down the path of whole banning of a family of plants and not a specific species.

Let me dispel the “our planet is dying crowd” if that is your reason for wanting Hemp grown in the United States then you’re an ignorant flake.  Shhhh sit down quietly in the back and let the adults talk.  The banning of hemp was political. Its industrial uses from rope to paint are far more valuable than the health benefits from hemp oil.   The 1930’s in the US was a destructive time to freedom.  There was a political fascination to how much control Communist Russia had over its citizens AND they seem to tolerate it, power is corrupting. Harry Anslinger, head of the Federal Bureau of Narcotics (1931-1962), pushed through legislation that had been crafted in secrecy for 2 years. The result was the 1937 Marijuana Tax Act that made hemp and marijuana illegal for any use. The banning of growing hemp hurt some very powerful men in the US in key industries and the expanding use of it as a fuel was about to let small farmers gain wealth as “oil producers”.  To un-ring this 80 year old bell today would mean that people who oppose the Democrat party would make millions of dollars and have direct access to the very liberal crowd that Democrats count on for votes.  To argue how much money the US economy would make from fixing this problem falls on deaf ears because of WHO would make the most money.  Farmers.  Farmers with money do not need government, can’t have that.

To fix the problem of letting someone else have money, in 2003, the U.S. Department of Health and Human Services filed a U.S. patent on CBD (#6630507) that covers CBD treatment for various neurodegenerative and inflammatory disorders. Because of the February 6, 2004, Federal Court Ruling Nos. 03-71366, 03-71693, every US citizen can legally use CBD (extracted from industrial hemp high in CBD without illegal amounts of THC that amount being above .3%/volume).  Don’t have to tax something you get a royalty from, we will just ignore that previous 5000  years of mans use of the product.

The purpose of our discussion on CBD is on the health side.

The first confusion we see is people asking “How do I get a prescription for CBD”, the answer is you do not and you do not need one. It is legal in all 50 states and the new legislation being written with broad strokes to entrap the Vaping industry is rolling CBD under that umbrella.  While this will cause further confusion it appears that the government intention is to just call vegetable oil Tobacco and be done with arguments.  It’s now tobacco, we tax tobacco, problem and argument settled.

CBD only medical Marijuana bills have been introduced and the hammer comes down from Hollywood and the High Times loyalist crowd.   You see Cannabis and Cannabidiol (CBD) are different.

Cannabis is a plant that lets you get the psychotropic THC for the lower risk high than other drugs.  Sorry it’s not risk free as ANYONE who has ever had a stoner come up and try to hold a conversation will attest.  Do not need a research grant to define BURNT.  Cannabis does contain some CBD but the more THC the less CBD and the two “drugs”/chemicals counteract each other.  While not everyone becomes damaged it is the reason I used the word RISK.  I am as I pointed out a libertarian and in my political thinking if you want to dip Oreo’s in rat poison I do not care as long as I don’t have to clean up the body.

Cannabidiol (CBD) is grown and tied to Hemp plant because of its very low THC, should be noted that THC is produced by the plants as a “sunscreen”.  To grow the two plants is so drastically different that the possibility of someone hiding a marijuana field inside a hemp field would not work.  One plant is 8 feet tall (hemp) the other only 5 feet and they require completely different soil nitrogen levels.  It still is illegal to grow hemp in the US because of concerns that law enforcement would not be able to tell the difference between the two plants.  Thus the close up shot of a leaf is what always sways the argument.

 

So in researching the benefits of CBD I came across some of the craziest people and we have weeded (all pun intended) through the mire of those deliberately trying to confuse the issue for the purpose of a legal high with what you came here for and that is:

“Will CBD help me?”

That is a great question and not one that should be answered by the guy trying to sell you CBD.  The retail price of CBD is around $1 / mg. The beauty of the product is you cannot overdose it so having someone use more means more money for the retailer.  The downfall is you do not get a high so you really have no good way to gauge the dose you’re taking so you as a consumer can keep your cost down.  I also found no good “here is how you know” because no one wants to be liable for anything.

I was first introduced to CBD just a few months ago and as a part of adding it our retail shops I wanted to fully understand my liability and legal responsibility.  More importantly I didn’t want someone puffing on a stick and falling asleep on the drive home from work, which was the first thought in my head reading the first things that popped up on Google on CBD.

I had surgery a few months ago on my back and years of broken bones as well as decades of working with tools which has the arthritis in my hands actually preventing me from sleeping.  So my curiosity was personal as well as professional.  Let me state clearly my personal use was investigative to both its effects and my possible liability.  So if it worked but made me dangerous on the road. I would keep using it just responsible, but most likely would not have sold it.

What I discovered was energy, ease in my arthritis for both my hands and my back.  So that made me dig further WHY was CBD working?

CBD has a few properties to it as a chemical. First it’s anti-inflammatory and on multitudes of tissue, lungs as well as muscles.   It’s theorized that this because of its ability to deliver more Oxygen to the tissue, but not really.  It allows the tissue to utilize oxygen more efficiently and require less of it.  So versions of CBD to patients on oxygen all the time has shown they use less oxygen.

There have been studies on Cancer that shown that higher levels of oxygen deliver helps to put Cancer in remission as well as high alkaline vs Base properties of the blood.  Which also has been stated to reduce cancer.  Health advocates have preached this balance to a better overall body health for decades now and CBD seems to obtain this balance on two fronts.

There is also a calming effect to CBD, so it winds up being recommend for the undiagnosed diseases such as “grandma frets to much over small stuff” and “My kids are on my last nerve syndrome”.   These are described as “mood enhancers” though the studies I have read show that there is no definable chemical for this effect even though it has been noted in all the studies.

Frankly it couldn’t be simpler.  Good oxygen in blood = Less pain which = better sleep, and you just feel better to handle your day with energy thus you’re in a better mood.  Not complicated from my reading yet not stated by anyone getting a grant.   There seems to be a committed plan to prove that the chemical fixes the problem and not a good night’s sleep. There is also research that suggests that CBD is very good for Anti-biotic resistant infections.   This seems to fall in line with other research as increasing oxygen levels would be the best way to combat these types of infections supporting your immune system with tons of fuel.

The “industry” likes to quote that CBD is some form of Cure-all and then the medical marijuana clingers recite these as if it were fact of all products containing CBD.   First of all the cure-all of CBD is NOT FACT and secondly the fact is that in marijuana, CBD is counter-acted by high quantities of THC somewhat nullify its effects, which is why medical users are looking for PURE CBD.  That said the following is the list of customer complaints that CBD is supposed to help with.  The Hyperlinks take you directly to PubMed.gov articles on published medical results not some third party forum

  • Anxiety and Depression / PTSD – PTSD is a sore issue with me as it has become its own political animal. The Democrat party platform is that ALL vets have PTSD. Truth is less than 15% even qualify for the VFW (Veterans of Foreign Wars) I being a lifetime member of the VFW can tell you need to have MEDALS that involve combat to be a member. If you do not qualify for the VFW you shouldn’t be getting a check for PTSD. As with all benefits to veterans it creeps into the civilian market. PTSD PREDATOR THREAT STRESS. If you haven’t been hunted by other human beings you do not have PTSD. Of the 15% that would even get into that first category to qualify less than .02% have problem medically shutting off the fight or flight response system. Not being able to shut this off keeps the adrenal gland going and OTHER THINGS CAN DO THIS AS WELL. Do not lump vets into a PTSD category with ignorance hoping to shut off a voting block by calling them “crazy” by another name. Step off my soap box for now. Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors. Repeated CBD administration prevents the long-lasting anxiogenic effects observed after predator exposure probably by facilitating 5HT1A receptors neurotransmission. Our results suggest that CBD has beneficial potential for PTSD treatment and that 5HT1A receptors could be a therapeutic target in this disorder.
  • Insomnia and sleep disorders – Recently, several groups have investigated the pharmacological properties of CBD with significant findings; furthermore, this compound has raised promising pharmacological properties as a wake-inducing drug. In the current review, we will provide experimental evidence regarding the potential role of CBD as a wake-inducing drug. This study is confusing as its meaning is about “alertness” while awake although it sounds like CBD keeps you up. The mind is more active when awake allowing for a better “Switch” to sleep brain fixing some sleep disorders is a more complete answer. Up to 40% of older adults have insomnia, with difficulty getting to sleep, early waking, or feeling unrefreshed on waking. The prevalence of insomnia increases with age. Other risk factors include psychological factors, stress, daytime napping, and hyperarousal.stress, daytime napping, and hyper arousal. In this systematic review, we present information relating to the effectiveness and safety of the following interventions: cognitive behavioral therapy for insomnia (CBT-I), exercise programs, and timed exposure to bright light. (Specific study that cross analysis sleep as it’s not as simple as puff and go to sleep CBD doesn’t make you sleepy. Activating your brain during the day wears you out so you will sleep.)
  • Arthritis /Pain and Inflammation / MS– The therapeutic potential of cannabidiol (CBD), the major nonpsychoactive component of cannabis, was explored in murine collagen-induced arthritis (CIA). CIA was elicited by immunizing DBA/1 mice with type II collagen (CII) in complete Freund’s adjuvant. The CII used was either bovine or murine, resulting in classical acute CIA or in chronic relapsing CIA, respectively. CBD was administered after onset of clinical symptoms, and in both models of arthritis the treatment effectively blocked progression of arthritis. CBD was equally effective when administered i.p. or orally. The dose dependency showed a bell-shaped curve, with an optimal effect at 5 mg/kg per day i.p. or 25 mg/kg per day orally. Clinical improvement was associated with protection of the joints against severe damage. Ex vivo, draining lymph node cells from CBD-treated mice showed a diminished CII-specific proliferation and IFN-gamma production, as well as a decreased release of tumor necrosis factor by knee synovial cells. In vitro effects of CBD included a dose-dependent suppression of lymphocyte proliferation, both mitogen-stimulated and antigen-specific, and the blockade of the Zymosan-triggered reactive oxygen burst by peritoneal granulocytes. It also was found that CBD administration was capable of blocking the lipopolysaccharide-induced rise in serum tumor necrosis factor in C57/BL mice. Taken together, these data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect in CIA.
  • Migraines – The literature suggests that the medicinal use of cannabis may have a therapeutic role for a multitude of diseases, particularly chronic pain disorders including headache. Supporting literature suggests a role for medicinal cannabis and cannabinoids in several types of headache disorders including migraine and cluster headache
  • Epilepsy and other neurological disorders /Spasms – Eighty-five percent of all parents reported a reduction in seizure frequency, and 14% reported complete seizure freedom. Epilepsy was characterized as highly refractory with median latency from epilepsy onset to CBD initiation of five years, during which the patient’s seizures failed to improve after a median of eight ant seizure medication trials. The median duration and the median dosage of CBD exposure were 6.8months and 4.3mg/kg/day, respectively. Reported side effects were far less common during CBD exposure, with the exception of increased appetite (30%). A high proportion of respondents reported improvement in sleep (53%), alertness (71%), and mood (63%) during CBD therapy. This study suggests a potential role for CBD in the treatment of refractory childhood epilepsy including IS and LGS
  • Cancer– Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner. Get that, yeah me neither and I have some medical background.
  • Diabetes – Remarkably, CBD attenuated myocardial dysfunction, cardiac fibrosis, oxidative/nitrative stress, inflammation, cell death, and interrelated signaling pathways. Furthermore, CBD also attenuated the high glucose-induced increased reactive oxygen species generation, nuclear factor-κB activation, and cell death in primary human cardiomyocytes.Yes, No, Maybe there is no THC in the CBD so you should not but what is called the 5 panel blood testing for “general presence” of cannabinoids, and don’t differentiate between CBD, THC, CBG, etc. The tests are exceptionally sensitive, measuring to 15 Nano grams of cannabinoids per liter of blood. There is a potential to test positive on workplace drug tests. Most workplaces have a drug “re-test” policy to drill down on what’s really present in the system – which in this case should be no THC. Inform the person taking your test that you use CBD and that should be enough to avoid the flag before it becomes an issue.
  • Most companies use the hair test for drug testing these days due to its extreme accuracy and being the lowest cost of the drug test available. Which wouldn’t flag because the THC is not present.

 

 

Will I pop positive on a drug test?

Yes, No, Maybe there is no THC in the CBD so you should not but what is called the 5 panel blood testing for “general presence” of cannabinoids, and don’t differentiate between CBD, THC, CBG, etc. The tests are exceptionally sensitive, measuring to 15 Nano grams of cannabinoids per liter of blood.

 

There is a potential to test positive on workplace drug tests. Most workplaces have a drug “re-test” policy to drill down on what’s really present in the system – which in this case should be no THC.  Inform the person taking your test that you use CBD and that should be enough to avoid the flag before it becomes an issue.

Most companies use the hair test for drug testing these days due to its extreme accuracy and being the lowest cost of the drug test available.  Which wouldn’t flag because the THC is not present.

 

Reference Links

  1. http://www.fda.gov/regulatoryinformation/legislation/ucm148726.htm
  2. http://www.ncbi.nlm.nih.gov/pubmed/21144973
  3. http://www.ncbi.nlm.nih.gov/pubmed/25903924
  4. http://www.ncbi.nlm.nih.gov/pubmed/25935511
  5. http://www.ncbi.nlm.nih.gov/pubmed/26015168
  6. http://www.ncbi.nlm.nih.gov/pubmed/25968443
  7. http://www.ncbi.nlm.nih.gov/pubmed/10920191

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1 Comment

  1. some fuzziness in the article that would turn this thing into a book if I filled all the holes. The 1937 act was found to be unconstitional in 1969 THATS why the 1970 act is what we currently operate under.

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